We developed novel, clinically applicable 3D virtual histopathology methods for different tumor types (thyroid, colorectal) using phase-contrast micro- and nano-CT methods . We combine imaging-based biomarker discovery with molecular (multi-omics) analysis to get a holistic approach to tumor diagnostic and patient management and prognosis. Furthermore, we apply radiomics methods in a novel approach on micro-CT of tissue micro arrays to couple underlying genetic mutations and other patient specific information with microscale tumor textures. We provide a major contribution to the establishment and development of the Swiss PHRT Imaging HUB. 

Figure caption: High-resolution phase-contrast nanoCT of a punch out core (600 micron diameter) from a whole biopsy block of colorectal tumor showing colonic crypts-green, necrotic cancer cell clusters- red and small tumor cells clusters (tumor budding) – blue (left). Registration of a H&E topslice with the 3D X-ray histopathology of a whole colorectal tumor biopsy block (right).