Damage to the cornea, due to injury or infection, can lead to vision impairment or blindness. Corneal diseases and injuries affect millions of people globally, particularly in developing countries where access to treatments is limited. Current treatments for corneal ulcers, such as suturing, synthetic glues or transplants, have significant drawbacks. Additionally, infections linked to corneal ulcers are increasingly resistant to antibiotics, making treatment more challenging.
To address these issues, we are developing a gelatin-based bioadhesive inspired by mussel foot proteins. This bioadhesive can be applied using a syringe for precise placement or as pre-formed patch that rehydrates on the eye, offering a flexible solution for sealing corneal wounds without the need for sutures. Antimicrobials (e.g antimicrobial peptides) can be incorporated into the adhesive to rapidly fight bacterial infections at the wound site. Additionally, the bioadhesive is strong enough to withstand mechanical pressure from eyelid movements.
Our goal is to create a sutureless, low-cost alternative to current treatments, addressing antibiotic resistance and reducing complications. This innovative bioadhesive offers an easy-to-use solution for treating corneal ulcers, particularly benefiting low- and middle-income countries.