Proper suturing remains the key to successful corneal transplantation, which is the most commonly performed transplantation type in the world. The overall incidence of post-transplantation infections was reported to be as high as 11.9% in developing countries, and suture-related problems are known as a major cause of these infections (up to 50%). Suture-related post-surgery complications, including surgical site infection and inflammation, remain major challenges for existing sutures used in corneal surgeries, which can have devastating consequences such as poor visual outcome and transplant failure. On the one hand, the space between placed sutures and the surrounding tissues is prone to microbial colonization. On the other hand, the friction between stiff sutures and soft tissues can cause epithelial erosion around the suture, which can promote suturing site infection, as well as tissue inflammation. In the project HydroSuture, we are developing hydrogel-coated sutures by using a microfluidic wet spinning (MWS) technology to address these challenges.