iSoldering is an innovative laser-based tissue soldering technology tailored for precision in ophthalmic surgery. It combines intelligent laser tissue soldering with integrated nanothermometry, allowing for controlled, localized, and high-performance tissue sealing—ideal for sensitive structures like the retina, cornea, and sclera. Unlike traditional suturing methods, which can lead to inflammation, infection, and scarring, iSoldering offers a non-invasive solution that minimizes thermal damage, enhances tissue healing, and reduces postoperative complications. The technology’s integrated nanothermometry enables real-time feedback on tissue temperature, ensuring precise energy application to achieve strong tissue bonding without damaging adjacent areas. This feature is particularly beneficial in ophthalmic surgeries where exact temperature control is critical to maintaining tissue integrity and function. Our initial studies suggest that iSoldering promotes improved surgical outcomes compared to conventional methods. The technology can be applied to both open and minimally invasive surgeries, expanding its utility across  and beyond ophthalmic applications.