The SafePlastChem Conference aims to map and assess the current knowledge of plastic chemicals, including their environmental fate, health risks, technological challenges, control measures, and industrial innovation and best practices. The conference seeks to fill a gap in the global dialogue by focusing specifically on plastic chemicals, which have been overlooked in past discussions on plastic pollution. By bringing together scientists from various disciplines—academia, industry, and regulatory sectors—the conference aims to develop a roadmap for managing plastic chemicals in a way that supports a sustainable, circular plastic economy.