Graphene dust not harmful, study finds

Confocal microscopy images of human lung cells in culture after exposure to the tested materials (left) and control cells. No signs of alterations were observed in cells exposed to the highest concentration of abraded particles compared to the negative control cultures Image: Empa / Journal of Hazardous Materials

The researchers analyzed and compared the effects of the abraded particles consisting of either PA6-rGO, PA6 alone or pure rGO along the most likely exposure routes. Therefore, they used cell-based models representing human lungs, the gastrointestinal tract, the skin and the immune system as well as an in vivo mouse model for pulmonary exposure.

The researcher found only limited acute responses after exposure to PA6-rGO in the different cell-based models. Only rGO induced substantial adverse effects, in particular in macrophages, a type of immune cells. Since inhalation of airborne materials is a key occupational concern, the team conducted a single exposure study in mice. In agreement with the acute in vitro data, PA6-rGO induced a modest and transient pulmonary inflammation. Overall this comprehensive study suggests a likely low risk to human health at acute exposure conditions of rGO-PA6. However, further studies would be required to assess chronic effects or impact on patients suffering from chronic obstructive pulmonary disease (COPD) or asthma.

“We aim to anticipate the ‘what if?’ scenario prior to the broad use of these emerging materials to avoid future social and economic drawbacks,” says Empa scientist Peter Wick, the lead author of the study. “We anticipated questions, which will become relevant for the 'Chemicals Strategy for sustainability towards a toxic-free environment' of the European Commission, facilitating the safe and sustainable use of GRM-reinforced materials. This was only possible thanks to a multidisciplinary team of experts in polymers, graphene and nanosafety, favored by the Graphene Flagship ecosystem.”

Andrea C. Ferrari, Science and Technology Officer of the Graphene Flagship and Chair of its Management Panel, adds: “This comprehensive study of possible toxicity of graphene-polymer composite fragments highlights the central role that health and safety plays in the Graphene Flagship since its very beginning. When these composites are processed into industrial parts, one needs to seriously consider the possible health implications due to emitted/abraded particles. It is reassuring to see this study shows negligible effects, thus confirming the viability of graphene for mass applications”.