Nanoparticles: Risk for babies in the womb

Human life begins with a single egg cell that grows into a human being with trillions of cells. To ensure that the highly complex development of tissues and organs is as protected as possible, the placental barrier keeps pathogens and foreign substances out. Tina Bürki and her team from Empa's Particles-Biology Interactions laboratory in St. Gallen are investigating how this protective mechanism copes with nanoparticles.

Nanoparticles are contained in a large number of products, but they are also produced during wear and tear as well as through combustion processes (see box). "We absorb these substances from the environment via our food, cosmetics or the air we breathe," explains Bürki. Some of these nanoparticles are suspected of harming babies in the womb. Low birth weight, autism and respiratory diseases are among the possible consequences for the child.

The researchers are currently investigating the entirety of the messenger substances released by a nanoparticle-treated placenta, the so-called secretome. Uncontaminated, the interplay of hormones, inflammatory mediators and signaling substances for the formation of organ systems resembles a perfectly tuned orchestra. It is already clear that the communication between the placenta and the unborn child is disrupted by the presence of nanoparticles and damages the formation of blood vessels. However, initial results show that the development of the nervous system does not appear to be affected. Future analyses will show what other disorders the nanoparticles can trigger indirectly. "As the effects can have an impact on the health of the pregnant woman and the development of her child, these findings should be taken into account in the risk assessment of nanomaterials," says the researcher.

The clinical partner, the Cantonal Hospital of St. Gallen, is also interested. As Thomas Rduch from the Women's Clinic and also a Clinical Research Fellow at Empa puts it: "A healthy placenta is of utmost importance for the development of the child. Correct risk assessments of environmental pollution are therefore crucial for pregnant women."

The placenta is an organ that forms exclusively during pregnancy. It supplies the child in the womb with nutrients and also serves as a filter for environmental influences. This so-called placental barrier offers the unborn child a certain degree of protection against pathogens or harmful substances. However, some substances, such as environmental oestrogens, can pass through the placental barrier and are suspected of being associated with various diseases. Image: Adobe Stock

Nanoparticles are only a few millionths of a millimeter in size. They include titanium dioxide, for example, which can be found in many foods, cosmetics and medicines. Silicon dioxide is found in paints and printing paper, for example, and is also used as a food additive. Other nanoparticles come from environmental pollution processes such as plastic abrasion (nanoplastics) or industrial soot. They can enter the human body via the respiratory tract, the digestive tract or the skin. As environmental pollution with nanoparticles is increasing, Empa is researching the health risks in various projects. Image: Adobe Stock 
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