The group Multi-omics for healthcare materials focuses on the mapping of disease-associated cellular signaling networks in order to inform precise imunoengineering solutions. Activities of the group are centered on generating and analyzing biomedical multi-omics datasets that can assist development of new materials for personalized healthcare applications. 

Our research work aims to enable rational design of new materials by capitalizing on large-scale biomedical datasets. This involves development of new software tools, employment of advanced data analytics and modeling of material properties. Through collaborations with material scientists, we evaluate the efficiency of the in silico designed functionalized nanoparticles and other modified materials. Together with clinical and industrial partners, we seek to implement these new concepts into next generation healthcare solutions.

Group's background

Research Activities

Team

Selected Publications

 T Totu#, J Bossart#, K Hast, C Li, M Rottmar, B Sobottka, G Yu, V Ayala-Nunez, M Buljan*: Delineation of signaling routes that underlie differences in macrophage phenotypic states. bioRxiv (2024) 

M Buljan*, A Banaei-Esfahani, P Blattmann, F Meier-Abt, W Shao, O Vitek, H Tang, R Aebersold*: A computational framework for the inference of protein complex remodeling from whole-proteome measurements. Nature Methods 20(3):1523-1529. (2023)

M Buljan*, P Wick: Tailoring design of nanomaterials and systems to individualize patient treatments. Chimia 76(3):236-241. (2022)

M Buljan, R Ciuffa, A van Drogen, A Vichalkovski, M Mehnert, G Rosenberger, S Lee, M Varjosalo, L Espona Pernas, V Spegg, B Snijder, R Aebersold*, M Gstaiger*: Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases. Molecular cell 79(3):504-520. (2020)

M Buljan, P Blattmann, R Aebersold*, M Boutros*: Systematic characterization of pan-cancer mutation clusters. Molecular systems biology 14(3): e7974. (2018)

JK White, AK Gerdin, NA Karp, E Ryder, M Buljan, JN Bussell, J Salisbury, S Clare, NJ Ingham, C Podrini, R Houghton, J Estabel, JR Bottomley, DG Melvin, D Sunter, NC Adams, L Baker, C Barnes, R Beveridge, E Cambridge, D Carragher, P Chana, K Clarke, Y Hooks, N Igosheva, C Ismail, H Jackson, L Kane, R Lacey, DT Lafont, M Lucas, S Maguire, K McGill, RE McIntyre, S Messager, L Mottram, L Mulderrig, S Pearson, HJ Protheroe, LA Roberson, G Salsbury, M Sanderson, D Sanger, C Shannon, PC Thompson, E Tuck, VE Vancollie, L Brackenbury, W Bushell, R Cook, P Dalvi, D Gleeson, B Habib, M Hardy, K Liakath-Ali, E Miklejewska, S Price, D Sethi, E Trenchard, D von Schiller, S Vyas, AP West, J Woodward, E Wynn, A Evans, D Gannon, M Griffiths, S Holroyd, V Iyer, C Kipp, M Lewis, W Li, D Oakley, D Richardson, D Smedley, C Agu, J Bryant, L Delaney, NI Gueorguieva, H Tharagonnet, AJ Townsend, D Biggs, E Brown, A Collinson, CE Dumeau, E Grau, S Harrison, James Harrison, Catherine E Ingle, Helen Kundi, Alla Madich, Danielle Mayhew, T Metcalf, S Newman, J Pass, L Pearson, H Reynolds, C Sinclair, H Wardle-Jones, M Woods, L Alexander, T Brown, F Flack, C Frost, N Griggs, S Hrnciarova, A Kirton, J McDermott, C Rogerson, G White, P Zielezinski, T DiTommaso, A Edwards, E Heath, MA Mahajan, B Yalcin, D Tannahill, DW Logan, DG MacArthur, J Flint, VB Mahajan, SH Tsang, I Smyth, FM Watt, WC Skarnes, G Dougan, DJ Adams, R Ramirez-Solis, A Bradley, KP Steel: Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes. Cell 154(2):452-464. (2013)